Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production

Author:

Chiang Samuel C. C.1,Theorell Jakob1,Entesarian Miriam23,Meeths Marie23,Mastafa Monika23,Al-Herz Waleed4,Frisk Per5,Gilmour Kimberly C.6,Ifversen Marianne7,Langenskiöld Cecilia8,Machaczka Maciej9,Naqvi Ahmed1011,Payne Jeanette12,Perez-Martinez Antonio13,Sabel Magnus8,Unal Ekrem14,Unal Sule15,Winiarski Jacek16,Nordenskjöld Magnus3,Ljunggren Hans-Gustaf1,Henter Jan-Inge2,Bryceson Yenan T.117

Affiliation:

1. Centre for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden;

2. Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;

3. Clinical Genetics Unit, Department of Molecular Medicine and Surgery, and Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden;

4. Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait;

5. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden;

6. Immunology Laboratory, Great Ormond Street Hospital, London, United Kingdom;

7. Department of Pediatrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark;

8. Department of Women's and Children's Health, University of Gothenburg, The Queen Silvia Children's Hospital, Gothenburg, Sweden;

9. Division of Hematology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden;

10. Aga Khan University, Karachi, Pakistan;

11. Hospital for Sick Children, Toronto, ON;

12. Sheffield Children's Hospital, Sheffield, United Kingdom;

13. Division of Pediatric Hematology-Oncology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain;

14. Division of Pediatric Hematology-Oncology, Department of Pediatrics, Erciyes University, Kayseri, Turkey;

15. Division of Pediatric Hematology, Hacettepe University, Ankara, Turkey;

16. Departments of Pediatrics and of Clinical Science Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; and

17. Broegelmann Research Laboratory, The Gades Institute, University of Bergen, Bergen, Norway

Abstract

Key Points Compared with cytotoxic T cells, NK cells share mechanisms for lytic granule release but more stringently control cytokine production. Analysis of CD57bright cytotoxic T-cell function may prove useful in the diagnosis of primary immunodeficiencies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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