Murine anti–third-party central-memory CD8+ T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells-Reference-Cited by-同舟云学术

Murine anti–third-party central-memory CD8+ T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells

Published:2013-02-14 Issue:7 Volume:121 Page:1220-1228
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ophir Eran¹,Or-Geva Noga¹,Gurevich Irina¹,Tal Orna¹,Eidelstein Yaki¹,Shezen Elias¹,Margalit Raanan¹,Lask Assaf¹,Shakhar Guy¹,Hagin David¹,Bachar-Lustig Esther¹,Reich-Zeliger Shlomit¹,Beilhack Andreas²,Negrin Robert³,Reisner Yair¹

Affiliation:

1. Department of Immunology, Weizmann Institute of Science, Rehovot, Israel;

2. Department of Medicine and Interdisciplinary Center for Clinical Research (IZKF), Würzburg University, Würzburg, Germany; and

3. Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA

Abstract

Key Points A new approach to achieving immune tolerance and mixed chimerism with relevance for hematopoietic stem cell and organ transplantation. Anti–third-party central memory T cells support engraftment with nonablative conditioning by sequestering and deleting anti-donor T cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/7/1220/1368110/zh800713001220.pdf

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5. Tolerance induction by megadose hematopoietic progenitor cells: expansion of veto cells by short-term culture of purified human CD34(+) cells.;Gur;Blood,2002

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