Promoting regulation via the inhibition of DNAM-1 after transplantation-Reference-Cited by-同舟云学术

Promoting regulation via the inhibition of DNAM-1 after transplantation

Published:2013-04-25 Issue:17 Volume:121 Page:3511-3520
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Koyama Motoko¹,Kuns Rachel D.¹,Olver Stuart D.¹,Lineburg Katie E.¹,Lor Mary¹,Teal Bianca E.¹,Raffelt Neil C.¹,Leveque Lucie¹,Chan Christopher J.²³⁴,Robb Renee J.¹,Markey Kate A.¹,Alexander Kylie A.¹,Varelias Antiopi¹,Clouston Andrew D.⁵,Smyth Mark J.²³⁴,MacDonald Kelli P. A.¹,Hill Geoffrey R.¹⁶

Affiliation:

1. The Queensland Institute of Medical Research, Brisbane, Australia;

2. Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Australia;

3. Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Prahran, Australia;

4. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia;

5. Envoi Pathology, Brisbane, Australia; and

6. Department of Bone Marrow Transplantation, Royal Brisbane Hospital, Brisbane, Australia

Abstract

Key Points The DNAM-1 adhesion and costimulatory pathway promotes GVHD via effects on regulatory T cells. Effective GVL can still occur in the absence of DNAM-1, making the pathway an attractive therapeutic target.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/17/3511/1364864/3511.pdf

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5. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule.;Bottino;J Exp Med,2003

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