Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

Author:

Schachtner Hannah1,Calaminus Simon D. J.1,Sinclair Amy2,Monypenny James3,Blundell Michael P.4,Leon Catherine5,Holyoake Tessa L.2,Thrasher Adrian J.4,Michie Alison M.2,Vukovic Milica2,Gachet Christian5,Jones Gareth E.3,Thomas Steven G.6,Watson Steve P.6,Machesky Laura M.1

Affiliation:

1. University of Glasgow College of Medical, Veterinary and Life Sciences and Beatson Institute for Cancer Research, Bearsden, Glasgow, UK;

2. Paul O’Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Gartnavel General Hospital, Glasgow, UK;

3. King’s College London, Randall Division, Guy’s Campus, London, UK;

4. Molecular Immunology Unit, Wolfson Centre for Gene Therapy of Childhood Diseases and Centre for Immunodeficiency, University College London Institute of Child Health, London, UK;

5. UMR_S949 INSERM-Université de Strasbourg, Etablissement Français du Sang-Alsace, Strasbourg, France; and

6. University of Birmingham, Edgbaston, Birmingham, UK

Abstract

Key PointsMurine and human megakaryocytes assemble podosomes. Megakaryocyte podosomes remodel matrix.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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