Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation

Author:

Popat Uday1,Mehta Rohtesh S.1,Rezvani Katayoun1,Fox Patricia2,Kondo Kayo1,Marin David1,McNiece Ian1,Oran Betul1,Hosing Chitra1,Olson Amanda1,Parmar Simrit1,Shah Nina1,Andreeff Michael1,Kebriaei Partow1,Kaur Indreshpal1,Yvon Eric1,de Lima Marcos3,Cooper Laurence J. N.1,Tewari Priti1,Champlin Richard E.1,Nieto Yago1,Andersson Borje S.1,Alousi Amin1,Jones Roy B.1,Qazilbash Muzaffar H.1,Bashir Qaiser1,Ciurea Stefan1,Ahmed Sairah1,Anderlini Paolo1,Bosque Doyle1,Bollard Catherine4,Molldrem Jeffrey J.1,Chen Julianne1,Rondon Gabriela1,Thomas Michael1,Miller Leonard5,Wolpe Steve5,Simmons Paul6,Robinson Simon1,Zweidler-McKay Patrick A.3,Shpall Elizabeth J.1

Affiliation:

1. Department of Stem Cell Transplantation and Cellular Therapy, and

2. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX;

3. Department of Medicine-Hematology and Oncology, Case Western Reserve University, Cleveland, OH;

4. Department of Blood and Marrow Transplantation, Children's National Hospital System and The George Washington University, Washington, DC;

5. Preclinical Research Department, Targazyme Inc., Carlsbad, OH; and

6. The Centre for Stem Cell Research, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center, Houston, TX

Abstract

Key Points Ex vivo fucosylation of cord blood cells improves their homing capacities, leading to faster neutrophil and platelet engraftments. This method is quick, safe, and does not require a GMP laboratory; therefore, it can be used widely.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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