A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesis-Reference-Cited by-同舟云学术

A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesis

Published:2013-06-06 Issue:23 Volume:121 Page:4758-4768
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Conway Amanda E.¹,Scotland Paula B.²,Lavau Catherine P.²,Wechsler Daniel S.¹²

Affiliation:

1. Department of Pharmacology and Cancer Biology, Duke University, Durham, NC; and

2. Division of Pediatric Hematology-Oncology, Duke University Medical Center, Durham, NC

Abstract

Key Points An NES within CALM is necessary and sufficient for CALM-AF10–mediated transformation. Presence of the CALM NES confers transformation potential to AF10 through perturbation of H3K79 methylation and Hoxa cluster expression.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/23/4758/1366406/4758.pdf

Reference55 articles.

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2. Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients.;Bohlander;Leukemia,2000

3. MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis.;Dreyling;Blood,1998

4. Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides.;Silliman;Leukemia,1998

5. The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice.;Deshpande;Leukemia,2011

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