Pharmacological inhibition of VIP signaling enhances antiviral immunity and improves survival in murine cytomegalovirus-infected allogeneic bone marrow transplant recipients-Reference-Cited by-同舟云学术

Pharmacological inhibition of VIP signaling enhances antiviral immunity and improves survival in murine cytomegalovirus-infected allogeneic bone marrow transplant recipients

Published:2013-03-21 Issue:12 Volume:121 Page:2347-2351
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Li Jian-Ming¹,Hossain Mohammad S.¹,Southerland Lauren²,Waller Edmund K.¹

Affiliation:

1. Department of Hematology/Oncology, Winship Cancer Institute, Emory University, Atlanta, GA; and

2. Duke University School of Medicine, Duke University, Durham, NC

Abstract

Key PointsA small-molecule peptide inhibitor of VIP-signaling protected murine allo-BMT recipients from lethal mCMV infection without increasing GvHD. Treatment with the VIP inhibitor reduced viral loads, increased antigen-specific T-cells, and decreased PD-1 expression.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/12/2347/1364143/2347.pdf

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