Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: relevance to post-remission therapy

Author:

Pratcorona Marta1,Brunet Salut2,Nomdedéu Josep2,Ribera Josep Maria3,Tormo Mar4,Duarte Rafael5,Escoda Lourdes6,Guàrdia Ramon7,Queipo de Llano M. Paz8,Salamero Olga9,Bargay Joan10,Pedro Carmen11,Martí Josep Maria12,Torrebadell Montserrat1,Díaz-Beyá Marina1,Camós Mireia13,Colomer Dolors1,Hoyos Montserrat2,Sierra Jorge2,Esteve Jordi1

Affiliation:

1. Hematology Department, Hospital Clínic, Institut d'investigacions biomèdiques August Pi i Sunyer, Barcelona, Spain;

2. Hematology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain;

3. Hematology Department, Institut Català D'Oncologia-Hospital Germans Trias i Pujol, Badalona, Spain;

4. Hematology Department, Hospital Clínico, Valencia, Spain;

5. Hematology Department, Hospital Duran i Reynals, L’Hospitalet de Llobregat, Spain;

6. Hematology Department, Hospital Joan XXIII, Tarragona, Spain;

7. Hematology Department, Hospital Josep Trueta, Girona, Spain;

8. Hematology Department, Hospital Virgen de la Victoria, Málaga, Spain;

9. Hematology Department, Hospital Vall d’Hebron, Barcelona, Spain;

10. Hematology Department, Hospital de Son Llàtzer, Palma de Mallorca, Spain;

11. Hematology Department, Hospital del Mar, Barcelona, Spain;

12. Hematology Department, Hospital Mútua de Terrassa, Terrassa, Spain; and

13. Hematology Department, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain

Abstract

Key Points In intermediate-risk AML, effect of FLT3 burden is modulated by NPM1 mutation, especially in patients with a low ratio. Combined evaluation of NPM1 mutation and FLT3-ITD burden might contribute to identify patients who benefit from early allogeneic HSCT.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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