Peptide length determines the outcome of TCR/peptide-MHCI engagement-Reference-Cited by-同舟云学术

Peptide length determines the outcome of TCR/peptide-MHCI engagement

Published:2013-02-14 Issue:7 Volume:121 Page:1112-1123
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ekeruche-Makinde Julia¹,Miles John J.¹²,van den Berg Hugo A.³,Skowera Ania⁴⁵,Cole David K.¹,Dolton Garry¹,Schauenburg Andrea J. A.¹,Tan Mai Ping¹,Pentier Johanne M.¹,Llewellyn-Lacey Sian¹,Miles Kim M.¹,Bulek Anna M.¹,Clement Mathew¹,Williams Tamsin¹,Trimby Andrew¹,Bailey Mick⁶,Rizkallah Pierre¹,Rossjohn Jamie¹⁷,Peakman Mark⁴⁵,Price David A.¹,Burrows Scott R.²,Sewell Andrew K.¹,Wooldridge Linda¹

Affiliation:

1. Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom;

2. Cellular Immunology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia;

3. Mathematics Institute, University of Warwick, Coventry, United Kingdom;

4. Department of Immunobiology, King's College London, London, United Kingdom;

5. National Institute for Health Research Biomedical Research Centre at Guy's & St Thomas' National Health Service Foundation Trust and King's College London, London, United Kingdom;

6. Division of Veterinary Pathology, Infection and Immunity, School of Clinical Veterinary Science, University of Bristol, Bristol, United Kingdom; and

7. Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Australia

Abstract

Key Points MHCI-restricted TCRs exhibit an explicit preference for a single MHCI-peptide length. Effective CD8+ T-cell immunity can only be achieved by length-matched Ag-specific T-cell clonotypes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/7/1112/1368455/zh800713001112.pdf

Reference50 articles.

1. The generation and fate of thymocytes.;Shortman;Semin Immunol,1990

2. Site-specific recombination in the immune system.;Lieber;FASEB J,1991

3. The nature of molecular recognition by T cells.;Davis;Nat Immunol,2003

4. A direct estimate of the human alphabeta T cell receptor diversity.;Arstila;Science,1999

5. Diversity of human alpha beta T cell receptors.;Arstila;Science,2000

Cited by 86 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. MHC1/LILRB1 axis as an innate immune checkpoint for cancer therapy;Frontiers in Immunology;2024-06-07

2. CRISPR-Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition;iScience;2024-06

3. Experimental validation of immunogenic SARS-CoV-2 T cell epitopes identified by artificial intelligence;Frontiers in Immunology;2023-11-17

4. Thioamide Analogues of MHC I Antigen Peptides;Journal of the American Chemical Society;2023-11-15

5. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy;Cell;2023-08