Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model-Reference-Cited by-同舟云学术

Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model

Published:2013-02-07 Issue:6 Volume:121 Page:996-1007
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ding Wanjing¹,Shimada Hiroyuki¹²,Li Lin¹,Mittal Rahul³,Zhang Xiaokun⁴,Shudo Koichi⁵,He Qiaojun⁶,Prasadarao Nemani V.²³,Wu Lingtao¹²

Affiliation:

1. Department of Pathology, Children's Hospital Los Angeles Saban Research Institute, Los Angeles, CA;

2. University of Southern California Keck School of Medicine, Los Angeles, CA;

3. Division of Infectious Diseases, Department of Pediatrics and Surgery, Children's Hospital Los Angeles Saban Research Institute, Los Angeles, CA;

4. Sanford-Burnham Medical Research Institute, La Jolla, CA;

5. Research Foundation ITSUU Laboratory, Tokyo, Japan; and

6. Institute of Pharmacology and Toxicology, Zhejiang University, Hangzhou, China

Abstract

Key PointsNeutrophils mobilized by Am80 display greater bactericidal activity than those by G-CSF. These findings suggest a molecular rationale for developing new therapy for neutropenia by using Am80 as a cost-effective treatment option.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/6/996/1368387/zh800613000996.pdf

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