A new approach for eradication of residual lymphoma cells by host nonreactive anti–third-party central memory CD8 T cells

Author:

Lask Assaf1,Ophir Eran1,Or-Geva Noga1,Cohen-Fredarow Adva1,Afik Ran1,Eidelstein Yaki1,Reich-Zeliger Shlomit1,Nathansohn Bar1,Edinger Matthias2,Negrin Robert S.3,Hagin David1,Reisner Yair1

Affiliation:

1. Immunology Department, Weizmann Institute of Science, Rehovot, Israel;

2. Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany; and

3. Bone Marrow Transplantation, Stanford University, Stanford, CA

Abstract

Key Points Anti–third-party Tcm kill malignant B cells in a T-cell receptor–independent mechanism while sparing naive B cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference33 articles.

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2. T-cell depletion of HLA-identical transplants in leukemia.;Marmont;Blood,1991

3. Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo-induced central memory CD8 T cells.;Ophir;Blood,2010

4. Ex vivo-induced donor central memory CD8 T-cells induce tolerance toward T-cell-depleted BM allografts under reduced conditioning and mediate GVL reactivity against B-cell malignancies, without causing GVHD.;Ophir;Bone Marrow Transplant,2011

5. Eradication of B-CLL by autologous and allogeneic host nonreactive anti-third-party CTLs.;Arditti;Blood,2005

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