SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma-Reference-Cited by-同舟云学术

SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma

Published:2013-03-21 Issue:12 Volume:121 Page:2175-2185
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vegliante Maria Carmela¹,Palomero Jara¹,Pérez-Galán Patricia¹,Roué Gaël¹,Castellano Giancarlo¹,Navarro Alba¹,Clot Guillem¹,Moros Alexandra¹,Suárez-Cisneros Helena¹,Beà Sílvia¹,Hernández Luis¹,Enjuanes Anna¹,Jares Pedro¹,Villamor Neus¹,Colomer Dolors¹,Martín-Subero José Ignacio²,Campo Elias¹²,Amador Virginia¹

Affiliation:

1. Hematopathology Unit, Pathology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer; and

2. Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain

Abstract

Key Points SOX11 silencing promotes the shift from a mature B cell into the initial plasmacytic differentiation phenotype in MCL. SOX11 promotes tumor growth of MCL cells in vivo, highlighting its implication in the aggressive behavior of conventional MCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/12/2175/1364453/2175.pdf

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