Early and nonreversible decrease of CD161++/MAIT cells in HIV infection-Reference-Cited by-同舟云学术

Early and nonreversible decrease of CD161++/MAIT cells in HIV infection

Published:2013-02-07 Issue:6 Volume:121 Page:951-961
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cosgrove Cormac¹,Ussher James E.¹,Rauch Andri²,Gärtner Kathleen³,Kurioka Ayako¹,Hühn Michael H.⁴,Adelmann Krista¹,Kang Yu-Hoi¹,Fergusson Joannah R.¹,Simmonds Peter³,Goulder Philip¹,Hansen Ted H.⁵,Fox Julie⁶,Günthard Huldrych F.⁷,Khanna Nina⁸,Powrie Fiona⁴,Steel Alan⁹,Gazzard Brian⁹,Phillips Rodney E.¹,Frater John¹,Uhlig Holm⁴,Klenerman Paul¹

Affiliation:

1. National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom;

2. Division of Infectious Diseases, University Hospital Berne and University of Berne, Berne, Switzerland;

3. Centre for Immunology, Infection and Evolution, Ashworth Laboratories, Edinburgh, United Kingdom;

4. Translational Gastroenterology Unit, Experimental Medicine, University of Oxford, Oxford, United Kingdom;

5. Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO;

6. Guys and St Thomas' National Health Service Trust/King's College London, Harrison Wing, St Thomas' Hospital, London, United Kingdom;

7. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland;

8. Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland; and

9. St Stephen's Centre, Chelsea and Westminster Hospital, London, United Kingdom

Abstract

Key PointsThe frequency of CD161++ MAIT cells is dramatically decreased in the blood of HIV-infected patients, and they are nonrecoverable with HAART. Gut sequestration and apoptosis in response to bacterial signals may, amongst others, be mechanisms that contribute to this.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/6/951/1367960/zh800613000951.pdf

Reference54 articles.

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2. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract.;Brenchley;J Exp Med,2004

3. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract.;Mehandru;J Exp Med,2004

4. Loss of mucosal CD4 lymphocytes is an early feature of HIV infection.;Lim;Clin Exp Immunol,1993

5. HIV-related oral disease.;Greenspan;Lancet,1996

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