MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma

Author:

Horn Heike1,Ziepert Marita2,Becher Claudia3,Barth Thomas F. E.4,Bernd Heinz-Wolfram5,Feller Alfred C.5,Klapper Wolfram6,Hummel Michael7,Stein Harald7,Hansmann Martin-Leo8,Schmelter Christopher9,Möller Peter4,Cogliatti Sergio10,Pfreundschuh Michael11,Schmitz Norbert12,Trümper Lorenz13,Siebert Reiner3,Loeffler Markus2,Rosenwald Andreas9,Ott German1

Affiliation:

1. Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;

2. Institute for Medical Informatics, Statistics, and Epidemiology, Universität Leipzig, Leipzig, Germany;

3. Institute of Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany;

4. Institute of Pathology, Universitätsklinikum Ulm, Ulm, Germany;

5. Institute of Pathology, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany;

6. Institute of Pathology, Hematopathology Section and Lymph Node Registry, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany;

7. Institute of Pathology, Campus Benjamin Franklin, Charité Universitätsmedizin, Berlin, Germany;

8. Institute of Pathology, Universitätsklinikum Frankfurt, Frankfurt, Germany;

9. Institute of Pathology, Universität Würzburg, Würzburg, Germany;

10. Institute of Pathology, Kantonal Hospital, St. Gallen, Switzerland;

11. Medizinische Klinik I, Saarland University Medical School, Homburg/Saar, Germany;

12. Department of Hematology, Asklepios Klinik St. Georg, Hamburg, Germany; and

13. Department of Hematology and Oncology, Georg-August Universität, Göttingen, Germany

Abstract

Key Points Outcome prediction in DLBCL. MYC status in concert with BCL2 and BCL6.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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