Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer-Reference-Cited by-同舟云学术

Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer

Published:2013-03-07 Issue:10 Volume:121 Page:1740-1748
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Schmidt Karin¹,Zilio Serena²,Schmollinger Jan C.¹,Bronte Vincenzo³,Blankenstein Thomas¹⁴,Willimsky Gerald¹⁴

Affiliation:

1. Institute of Immunology, Charité Campus Buch, Berlin, Germany;

2. Istituto Oncologico Veneto, Istituiti di Ricovero e Cura a Carattere Scientifico, Padova, Italy;

3. Verona University Hospital and Department of Pathology, Immunology Section, Verona, Italy; and

4. Max Delbrück Center for Molecular Medicine, Berlin, Germany

Abstract

Key Points iMC expand independent of the type of antitumor response and are not immunosuppressive in a cell-autonomous fashion iMC are licensed to become MDSC in vivo in the presence of GM-CSF

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/10/1740/1362846/1740.pdf

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4. Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells.;Gabrilovich;J Immunol,2001

5. Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity.;Melani;Blood,2003

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