Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation-Reference-Cited by-同舟云学术

Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation

Published:2013-03-07 Issue:10 Volume:121 Page:1839-1849
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kurotaki Daisuke¹,Osato Naoki¹,Nishiyama Akira¹,Yamamoto Michio¹,Ban Tatsuma¹,Sato Hideaki¹,Nakabayashi Jun¹,Umehara Marina¹,Miyake Noriko²,Matsumoto Naomichi²,Nakazawa Masatoshi³,Ozato Keiko⁴,Tamura Tomohiko¹

Affiliation:

1. Department of Immunology,

2. Department of Human Genetics, and

3. Department of Experimental Animal Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

4. Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD

Abstract

Key Points IRF8 induces the Klf4 gene in myeloid progenitors; this transcription factor cascade is essential for Ly6C+ monocyte development. IRF8 binding to genomic targets promotes H3K4me1, a chromatin signature for promoter-distal enhancers, thereby inducing gene expression.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/10/1839/1363628/1839.pdf

Reference45 articles.

1. Development of monocytes, macrophages, and dendritic cells.;Geissmann;Science,2010

2. Blood monocytes: development, heterogeneity, and relationship with dendritic cells.;Auffray;Annu Rev Immunol,2009

3. Distinct differentiation potential of blood monocyte subsets in the lung.;Landsman;J Immunol,2007

4. Myeloid lineage commitment from the hematopoietic stem cell.;Iwasaki;Immunity,2007

5. Studying the mononuclear phagocyte system in the molecular age.;Chow;Nat Rev Immunol,2011

Cited by 202 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Spleen-liver dual accumulation of ly6clowExo potentiates synergistic immune modulation for liver fibrosis therapy;Nano Today;2024-10

2. The intervention of macrophages in progressive fibrosis characterizing systemic sclerosis: A systematic review;Autoimmunity Reviews;2024-10

3. Application of methylation in the diagnosis of ankylosing spondylitis;Clinical Rheumatology;2024-08-21

4. OneSC: A computational platform for recapitulating cell state transitions;2024-06-03

5. IRF8 maintains mononuclear phagocyte and neutrophil function in acute kidney injury;Heliyon;2024-06