Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation-Reference-Cited by-同舟云学术

Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation

Published:2013-03-07 Issue:10 Volume:121 Page:1839-1849
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kurotaki Daisuke¹,Osato Naoki¹,Nishiyama Akira¹,Yamamoto Michio¹,Ban Tatsuma¹,Sato Hideaki¹,Nakabayashi Jun¹,Umehara Marina¹,Miyake Noriko²,Matsumoto Naomichi²,Nakazawa Masatoshi³,Ozato Keiko⁴,Tamura Tomohiko¹

Affiliation:

1. Department of Immunology,

2. Department of Human Genetics, and

3. Department of Experimental Animal Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

4. Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD

Abstract

Key Points IRF8 induces the Klf4 gene in myeloid progenitors; this transcription factor cascade is essential for Ly6C+ monocyte development. IRF8 binding to genomic targets promotes H3K4me1, a chromatin signature for promoter-distal enhancers, thereby inducing gene expression.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/10/1839/1363628/1839.pdf

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