Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model-Reference-Cited by-同舟云学术

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model

Published:2018-02-01 Issue:5 Volume:131 Page:558-562
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhu Xingguo¹,Xi Caixia²,Thomas Bobby³,Pace Betty S.¹²⁴

Affiliation:

1. Division of Hematology/Oncology, Department of Pediatrics,

2. Georgia Cancer Center,

3. Department of Pharmacology and Toxicology, and

4. Department of Biochemistry and Molecular Biology, Augusta University, Augusta, GA

Abstract

Key Points NRF2 knockout inhibits fetal hemoglobin expression during gestational erythropoiesis in SCD mice. Loss of the cellular antioxidant response mediated by NRF2 exacerbates spleen damage, inflammation, and oxidative stress in SCD mice.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/5/558/1466201/blood810531.pdf

Reference25 articles.

1. Mortality in sickle cell disease. Life expectancy and risk factors for early death;Platt;N Engl J Med,1994

2. Sickle-cell disease;Rees;Lancet,2010

3. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain;Itoh;Genes Dev,1999

4. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region;Moi;Proc Natl Acad Sci USA,1994

5. Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina;Promsote;Invest Ophthalmol Vis Sci,2014

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Impacts of oxidative stress and anti-oxidants on the development, pathogenesis, and therapy of sickle cell disease: A comprehensive review;Biomedicine & Pharmacotherapy;2024-07

2. The crucial role of NRF2 in erythropoiesis and anemia: Mechanisms and therapeutic opportunities;Archives of Biochemistry and Biophysics;2024-04

3. Simvastatin-Mediated Nrf2 Activation Induces Fetal Hemoglobin and Antioxidant Enzyme Expression to Ameliorate the Phenotype of Sickle Cell Disease;Antioxidants;2024-03-11

4. Bach1 inhibitor HPP-D mediates γ-globin gene activation in sickle erythroid progenitors;Blood Cells, Molecules, and Diseases;2024-01

5. Fatty acid nitroalkenes – Multi-target agents for the treatment of sickle cell disease;Redox Biology;2023-12