Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia

Published:2018-06-28 Issue:26 Volume:131 Page:2929-2942
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wang Fan¹,Demir Salih²,Gehringer Franziska¹,Osswald Clarissa D.¹,Seyfried Felix²,Enzenmüller Stefanie²,Eckhoff Sarah M.²,Maier Thomas¹,Holzmann Karlheinz³,Debatin Klaus-Michael²,Wirth Thomas¹,Meyer Lüder H.²,Ushmorov Alexey¹

Affiliation:

1. Institute of Physiological Chemistry, University of Ulm, Ulm, Germany;

2. Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and

3. Core Facility Genomics, University of Ulm, Ulm, Germany

Abstract

Key Points FOXO1 activity is essential for growth and maintenance of BCP-ALL. Inhibition of FOXO1 reduces leukemia load and prolongs survival in a preclinical model of BCP-ALL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/26/2929/1466254/blood813576.pdf

Reference60 articles.

1. Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia;Müschen;Blood,2015

2. Classification of lymphoid neoplasms: the microscope as a tool for disease discovery;Jaffe;Blood,2008

3. Mechanisms of pre-B-cell receptor checkpoint control and its oncogenic subversion in acute lymphoblastic leukemia;Buchner;Immunol Rev,2015

4. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia;Geng;Cancer Cell,2015

5. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate;Lin;Nat Immunol,2010

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