Long-range gene regulation and novel therapeutic applications-Reference-Cited by-同舟云学术

Long-range gene regulation and novel therapeutic applications

Published:2015-03-05 Issue:10 Volume:125 Page:1521-1525
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

van den Heuvel Anita¹,Stadhouders Ralph¹,Andrieu-Soler Charlotte²,Grosveld Frank¹,Soler Eric³

Affiliation:

1. Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands;

2. INSERM UMRS 1138, Team 17, Paris, France; and

3. INSERM UMR967, CEA/DSV/iRCM, Laboratory of Molecular Hematopoiesis, Fontenay-aux-Roses, France

Abstract

Abstract An intimate relationship exists between nuclear architecture and gene activity. Unraveling the fine-scale three-dimensional structure of the genome and its impact on gene regulation is a major goal of current epigenetic research, one with direct implications for understanding the molecular mechanisms underlying human phenotypic variation and disease susceptibility. In this context, the novel revolutionary genome editing technologies and emerging new ways to manipulate genome folding offer new promises for the treatment of human disorders.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/10/1521/1382621/1521.pdf

Reference80 articles.

1. An integrated encyclopedia of DNA elements in the human genome.;ENCODE Project Consortium;Nature,2012

2. Defining functional DNA elements in the human genome.;Kellis;Proc Natl Acad Sci USA,2014

3. What does our genome encode?;Stamatoyannopoulos;Genome Res,2012

4. Enhancer function: new insights into the regulation of tissue-specific gene expression.;Ong;Nat Rev Genet,2011

5. Functional and mechanistic diversity of distal transcription enhancers.;Bulger;Cell,2011

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Genetic pathways regulating the longitudinal acquisition of cocaine self-administration in a panel of inbred and recombinant inbred mice;Cell Reports;2023-08

2. Erythroid Cell Research: 3D Chromatin, Transcription Factors and Beyond;International Journal of Molecular Sciences;2022-05-30

3. Enhancers, spatial chromosome structuring and pathological changes: towards a better understanding of complex genome alterations;Hématologie;2021-06

4. Regulation of MYB by distal enhancer elements in human myeloid leukemia;Cell Death & Disease;2021-02

5. Tissue Regeneration Enhancer Elements: A Way to Unlock Endogenous Healing Power;Developmental Dynamics;2018-11-28