Platelets support a protective immune response to LCMV by preventing splenic necrosis-Reference-Cited by-同舟云学术

Platelets support a protective immune response to LCMV by preventing splenic necrosis

Published:2013-02-07 Issue:6 Volume:121 Page:940-950
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Loria Gilbert David¹²,Romagnoli Pablo A.¹,Moseley Nelson B.¹,Rucavado Alexandra³,Altman John D.¹

Affiliation:

1. Emory Vaccine Center and Department of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA;

2. Laboratorio de Virología, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica; and

3. Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

Abstract

Key PointsLevels of circulating platelets determine the degree of pathology observed during arenavirus infections. While moderate platelet drops result in deficient immune control of an LCMV infection, severe platelet-drops result in systemic hemorrhages.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/6/940/1368099/zh800613000940.pdf

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