Notch1 regulates angio-supportive bone marrow–derived cells in mice: relevance to chemoresistance

Author:

Roodhart Jeanine M. L.1,He Huanhuan2,Daenen Laura G. M.1,Monvoisin Arnaud3,Barber Chad L.4,van Amersfoort Miranda1,Hofmann Jennifer J.4,Radtke Freddy5,Lane Timothy F.46,Voest Emile E.1,Iruela-Arispe M. Luisa34

Affiliation:

1. Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands;

2. Department of Human Genetics,

3. Department of Molecular, Cell and Developmental Biology, and

4. Molecular Biology Institute, UCLA, Los Angeles, CA;

5. Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland; and

6. Department of Obstetrics and Gynecology and Biological Chemistry, UCLA, Los Angeles, CA

Abstract

Key Points Exposure to chemotherapy promotes the exit of specific subpopulations of BMDCs with angio-supportive activity. Notch in BMDCs is required for the exit of these cells from the bone marrow and for chemotherapy-enhanced angiogenesis in tumors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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