CD9, a key actor in the dissemination of lymphoblastic leukemia, modulating CXCR4-mediated migration via RAC1 signaling-Reference-Cited by-同舟云学术

CD9, a key actor in the dissemination of lymphoblastic leukemia, modulating CXCR4-mediated migration via RAC1 signaling

Published:2015-10-08 Issue:15 Volume:126 Page:1802-1812
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Arnaud Marie-Pierre¹²,Vallée Audrey¹²,Robert Guillaume¹²³,Bonneau Jacinthe¹²³,Leroy Christine⁴,Varin-Blank Nadine⁴,Rio Anne-Gaëlle¹²,Troadec Marie-Bérengère¹²,Galibert Marie-Dominique¹²⁵,Gandemer Virginie¹²³

Affiliation:

1. Centre National de la Recherche Scientifique (CNRS) Unités Mixtes de Recherche (UMR) 6290, Institut de Génétique et Développement de Rennes and

2. Structure Fédérative de Recherche (SFR) en Biologie et Santé de Rennes Biosit, Unité Mixte de Service (UMS) CNRS 3480/US INSERM 018, Université de Rennes 1, Rennes, France;

3. Department of OncoPediatrics, Rennes University Hospital, Rennes, France;

4. INSERM UMR U978, Adaptateurs de Signalisation en Hématologie, Université Paris 13, Unité de Formation et de Recherche (UFR) de Santé, Médecine et Biologie Humaine (SMBH), Bobigny, France; and

5. Department of Medical Genomic, Rennes University Hospital, Rennes, France

Abstract

Key Points CD9 expression enhances the CXCL12-induced migration of pre-B leukemic lymphocytes via RAC1 signaling. CD9 influences the chemotactic migration and engraftment of pre-B leukemic cells in NOD/SCID mouse testis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/15/1802/1390139/1802.pdf

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