Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach

Author:

Ciciliano Jordan C.1234,Sakurai Yumiko234,Myers David R.234,Fay Meredith E.234,Hechler Beatrice5,Meeks Shannon3,Li Renhao3,Dixon J. Brandon12,Lyon L. Andrew6,Gachet Christian5,Lam Wilbur A.234

Affiliation:

1. Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA;

2. Wallace C Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA;

3. Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children’s Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA;

4. Institute of Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA;

5. INSERM, Unité Mixte de Recherche S949, Etablissement Français du Sang-Alsace, Université de Strasbourg, Strasbourg, France; and

6. School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA

Abstract

Key Points The multivariate mechanism of FeCl3-induced thrombosis is rooted in colloidal chemistry, mass transfer, and biological clotting. FeCl3-induced thrombosis is mediated by charge-based binding of proteins (cell surface bound and soluble) to the Fe3+ ion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference37 articles.

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2. Rat model of arterial thrombosis induced by ferric chloride.;Kurz;Thromb Res,1990

3. Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice.;Farrehi;Circulation,1998

4. A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis.;Denis;Proc Natl Acad Sci USA,1998

5. Effects of factor XI deficiency on ferric chloride-induced vena cava thrombosis in mice.;Wang;J Thromb Haemost,2006

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