Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation-Reference-Cited by-同舟云学术

Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation

Published:2015-06-25 Issue:26 Volume:125 Page:4103-4113
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhou Xiaoou¹,Dotti Gianpietro¹,Krance Robert A.¹,Martinez Caridad A.¹,Naik Swati¹,Kamble Rammurti T.¹,Durett April G.¹,Dakhova Olga¹,Savoldo Barbara¹,Di Stasi Antonio¹,Spencer David M.²,Lin Yu-Feng¹,Liu Hao³,Grilley Bambi J.¹,Gee Adrian P.¹,Rooney Cliona M.¹,Heslop Helen E.¹,Brenner Malcolm K.¹

Affiliation:

1. Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital and Houston Methodist Hospital, Houston, TX;

2. Bellicum Pharmaceuticals, Inc., Houston, TX; and

3. Biostatistics Shared Resource, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX

Abstract

Key PointsAlloreplete iC9-T cells can promote immune recovery posttransplant and protect patients against viral infections. iC9-T cells can be eliminated from both peripheral blood and CNS by administration of AP1903 leading to a rapid resolution of GVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/26/4103/1387280/4103.pdf

Reference46 articles.

1. Immune reconstitution without graft-versus-host disease after haemopoietic stem-cell transplantation: a phase 1/2 study.;André-Schmutz;Lancet,2002

2. Haploidentical stem cell transplantation for children with high-risk leukemia.;Palma;Pediatr Blood Cancer,2012

3. Reduced-intensity allogeneic transplantation using alemtuzumab from HLA-matched related, unrelated, or haploidentical related donors for patients with hematologic malignancies.;Kanda;Biol Blood Marrow Transplant,2014

4. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype.;Aversa;N Engl J Med,1998

5. Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse.;Aversa;J Clin Oncol,2005

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