Race influences warfarin dose changes associated with genetic factors

Author:

Limdi Nita A.1,Brown Todd M.2,Yan Qi3,Thigpen Jonathan L.4,Shendre Aditi5,Liu Nianjun6,Hill Charles E.7,Arnett Donna K.5,Beasley T. Mark6

Affiliation:

1. Department of Neurology and

2. Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, AL;

3. Department of Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA;

4. Department of Clinical and Administrative Sciences, Notre Dame of Maryland University School of Pharmacy, Baltimore, MD;

5. Department of Epidemiology and

6. Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL; and

7. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA

Abstract

Key Points The influence of known genetic variants on warfarin dose differs by race. Race-specific pharmacogenetic algorithms, rather than race-adjusted algorithms, should be used to guide warfarin dosing.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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