Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner

Author:

Yi Weiwei1,Hu Xuelian2,Chen Zhiyang13,Liu Leiming14,Tian Yuan2,Chen Hui2,Cong Yu-sheng1,Yang Fan2,Zhang Lianfeng5,Rudolph Karl Lenhard3,Zhang Zhixin6,Zhao Yong2,Ju Zhenyu1

Affiliation:

1. Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, China;

2. Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China;

3. Leibniz Institute for Age Research–Fritz Lipmann Institute, Jena, Germany;

4. Sir Runrun Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China;

5. Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and

6. Department of Pediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy, Ministry of Education Key Laboratory of Birth Defects, Sichuan University, Chengdu, China

Abstract

Key Points Wip1 controls antigen-independent B-cell development in the bone marrow via a p53-dependent pathway. Wip1 is essential to prevent an aging-related decline in B-cell development.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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