L-selectin controls trafficking of chronic lymphocytic leukemia cells in lymph node high endothelial venules in vivo-Reference-Cited by-同舟云学术

L-selectin controls trafficking of chronic lymphocytic leukemia cells in lymph node high endothelial venules in vivo

Published:2015-09-10 Issue:11 Volume:126 Page:1336-1345
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lafouresse Fanny¹²,Bellard Elisabeth¹²,Laurent Camille³⁴⁵,Moussion Christine¹²,Fournié Jean-Jacques²³,Ysebaert Loïc³⁶,Girard Jean-Philippe¹²

Affiliation:

1. Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France;

2. Université de Toulouse, Université Paul Sabatier, Toulouse, France;

3. Centre de Recherches en Cancérologie de Toulouse, INSERM U1037, Toulouse, France;

4. Centre de Physiopathologie de Toulouse Purpan, INSERM U563, Toulouse, France; and

5. Laboratoire d’Anatomie et Cytologie Pathologiques, and

6. Service d’Hématologie, Institut Universitaire du Cancer Toulouse–Oncopôle, Toulouse, France

Abstract

Key Points In vivo imaging reveals that CLL cells bind to lymph node high endothelial venules via an L-selectin–dependent multistep adhesion cascade. Interference with L-selectin–mediated trafficking in high endothelial venules could limit dissemination of CLL cells to lymph nodes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/11/1336/1387915/1336.pdf

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