Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study

Author:

Inaba Hiroto1,Zhou Yinmei1,Abla Oussama2,Adachi Souichi34,Auvrignon Anne5,Beverloo H. Berna67,de Bont Eveline78,Chang Tai-Tsung910,Creutzig Ursula1112,Dworzak Michael13,Elitzur Sarah14,Fynn Alcira1516,Forestier Erik1718,Hasle Henrik1819,Liang Der-Cherng1020,Lee Vincent2122,Locatelli Franco2324,Masetti Riccardo2425,De Moerloose Barbara2627,Reinhardt Dirk1228,Rodriguez Laura2,Van Roy Nadine2627,Shen Shuhong29,Taga Takashi430,Tomizawa Daisuke431,Yeoh Allen E. J.32,Zimmermann Martin1112,Raimondi Susana C.1

Affiliation:

1. St. Jude Children's Research Hospital, Memphis, TN;

2. The Hospital for Sick Children, Toronto, ON, Canada;

3. Kyoto University, Kyoto, Japan;

4. Japanese Pediatric Leukemia/Lymphoma Study Group, Nagoya, Japan;

5. French Leucémie Aigue Myeloide Enfant, Hôpital Trousseau, Paris, France;

6. Erasmus Medical Center, Rotterdam, The Netherlands;

7. Dutch Childhood Oncology Group, The Hague, The Netherlands;

8. University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

9. Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;

10. Taiwan Pediatric Oncology Group, Taipei, Taiwan;

11. Medical School Hannover, Hannover, Germany;

12. Acute Myeloid Leukemia-Berlin-Frankfurt-Munster Study Group, Essen, Germany;

13. St. Anna Children’s Hospital, Medical University of Vienna, Vienna, Austria;

14. Schneider Children’s Medical Center of Israel, Petah-Tikva, Israel;

15. Children’s Hospital La Plata, La Plata, Buenos Aires, Argentina;

16. Grupo Argentino de Tratamiento de la Leucemia Aguda, Buenos Aires, Argentina;

17. Umeå University Hospital, Umea, Sweden;

18. Nordic Society for Pediatric Hematology and Oncology, Stockholm, Sweden;

19. Aarhus University Hospital, Skejby, Aarhus, Denmark;

20. Mackay Memorial Hospital, Taipei, Taiwan;

21. Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China;

22. Hong Kong Paediatric Haematology and Oncology Study Group, Hong Kong, China;

23. Istituto di Ricovero e Cura a Carattere Scientifico, Bambino Gesù Children’s Hospital Rome, University of Pavia, Rome, Italy;

24. Associazione Italiana Ematologia Oncologia Pediatrica, Bologna, Italy;

25. Ospedale Sant’Orsola-Malpighi, Bologna, Italy;

26. Ghent University Hospital, Gent, Belgium;

27. European Organisation for Research and Treatment of Cancer, Brussels, Belgium;

28. University Children’s Hospital, Essen, Germany;

29. Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China;

30. Shiga University of Medical Science, Shiga, Japan;

31. National Center for Child Health and Development, Tokyo, Japan; and

32. National University Cancer Institute, National University Health System, Singapore, Singapore

Abstract

Key Points AMKL patients in 2000 to 2009 had better survival than those in 1989 to 1999, but outcomes for patients in 2000 to 2004 and 2005 to 2009 were comparable. Heterogeneous cytogenetic groups can be classified into good, intermediate, and poor risk on the basis of prognosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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