Platelet-derived Wnt antagonist Dickkopf-1 is implicated in ICAM-1/VCAM-1–mediated neutrophilic acute lung inflammation-Reference-Cited by-同舟云学术

Platelet-derived Wnt antagonist Dickkopf-1 is implicated in ICAM-1/VCAM-1–mediated neutrophilic acute lung inflammation

Published:2015-11-05 Issue:19 Volume:126 Page:2220-2229
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Guo Yujie¹²,Mishra Amarjit¹,Howland Emily¹,Zhao Chunling¹,Shukla Dhananjay¹,Weng Tingting¹,Liu Lin¹²^ORCID

Affiliation:

1. Lundberg-Kienlen Lung Biology and Toxicology Laboratory, Department of Physiological Sciences and

2. Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, OK

Abstract

Key Points Platelet-derived Dkk1 is the major Wnt antagonist that suppresses Wnt/β-catenin signaling during acute lung inflammation. Intratracheal administration of Wnt3a or neutralization of Dkk1 inhibited neutrophil influx into the lungs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/19/2220/1345593/2220.pdf

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