Mechanisms of PD-L1/PD-1–mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model-Reference-Cited by-全球学者库

Mechanisms of PD-L1/PD-1–mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model

Published:2015-07-09 Issue:2 Volume:126 Page:212-221
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

McClanahan Fabienne¹²^ORCID,Riches John C.¹,Miller Shaun¹,Day William P.¹,Kotsiou Eleni¹,Neuberg Donna³^ORCID,Croce Carlo M.⁴^ORCID,Capasso Melania⁵^ORCID,Gribben John G.¹^ORCID

Affiliation:

1. Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom;

2. Department of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany;

3. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA;

4. Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH; and

5. Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

Abstract

Key Points PD-L1/PD-1–mediated CD8 T-cell dysfunction develops with CLL in different organs, and similarities to aging-related immune defects exist. PD-1+ normal T cells have markedly different effector functions than PD-1+ CLL T cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/2/212/1390425/212.pdf

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