Affiliation:
1. Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas
Abstract
The most widely recognized long-term risk of splenectomy is overwhelming bacterial infection. More recently, thrombosis has become appreciated as another potential complication of the procedure. Because of these long-term risks, the indications for and timing of splenectomy are debated in the medical community. Accordingly, the adverse effects and benefits of splenectomy for hematologic disorders and other conditions demand further study. This comprehensive review summarizes the existing literature pertaining to vascular complications after splenectomy for hematologic conditions and attempts to define the potential pathophysiologic mechanisms involved. This complex topic encompasses diverse underlying conditions for which splenectomy is performed, diverse thrombotic complications, and multiple pathophysiologic mechanisms.
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Reference142 articles.
1. Syndrome of asplenia and polysplenia: a review of cardiac and non-cardiac malformations in 60 cases with special references to diagnosis and prognosis.;Rose;Br Heart J,1975
2. National Hospital Discharge Survey: 2005 annual summary with detailed diagnosis and procedure data. National Center for Health Statistics.;DeFrances;Vital Health Stat,2007
3. The spleen as a diagnostic specimen.;Kraus;Cancer,2001
4. The incidence of splenectomy is decreasing: lessons learned from trauma experience.;Rose;Am Surg,2000
5. Hazard of overwhelming infection after splenectomy in childhood.;Eraklis;N Engl J Med,1967
Cited by
268 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献