Tvt CAR7: Phase 1 Clinical Trial of Base-Edited "Universal” CAR7 T Cells for Paediatric Relapsed/Refractory T-ALL

Author:

Chiesa Robert1,Georgiadis Christos2,Ottaviano Giorgio12,Syed Farhatullah23,Braybrook Toni2,Etuk Annie2,Zhan Hong2,Gkazi Soragia Athina2,Preece Roland2,Adams Stuart4,Thomas Rebecca5,Awuah Arnold6,Gilmour Kimberly6,Mhaldien Lana6,Chu Jan1,Pinner Danielle1,Kubat Agnieszka2,Veys Paul1,Rao Kanchan1,Lucchini Giovanna1,O'Connor David57,Vora Ajay5,Qasim Waseem2

Affiliation:

1. 1Department of Blood and Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom

2. 2Molecular and Cellular Immunology Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

3. 3King Faisal Specialist Hospital & Research Centre (KFSH&RC), Riyadh, Saudi Arabia

4. 4SIHMDS-Haematology, Great Ormond Street Hospital for Children, London, United Kingdom

5. 5Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom

6. 6Department of Immunology, Great Ormond Street Hospital for Children, London, United Kingdom

7. 7UCL Cancer Institute, Department of Haematology, University College London, London, United Kingdom

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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