Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation-Reference-Cited by-同舟云学术

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation

Published:2014-01-23 Issue:4 Volume:123 Page:520-529
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Keil Eric¹,Finkenstädt David¹,Wufka Christian¹,Trilling Mirko²,Liebfried Pia¹,Strobl Birgit³,Müller Mathias³,Pfeffer Klaus¹

Affiliation:

1. Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, Düsseldorf, Germany;

2. Institute for Virology, University Hospital Essen, University Duisburg-Essen, Essen, Germany; and

3. Institute of Animal Breeding and Genetics/Biomodels Austria, University of Veterinary Medicine, Vienna, Austria

Abstract

Key Points Jak2 activation-loop–defective mutation results in partial interferon γ signaling, but Jak2 mutant mice die due to abolished EpoR signaling. Jak2 scaffold function mediates IFNGR complex integrity, activity, and physiological Jak1 localization.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/4/520/1378662/520.pdf

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4. Janus kinase deregulation in leukemia and lymphoma.;Chen;Immunity,2012

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