Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study

Author:

Locatelli Franco1,Crotta Alessandro2,Ruggeri Annalisa23,Eapen Mary4,Wagner John E.5,MacMillan Margaret L.5,Zecca Marco6,Kurtzberg Joanne7,Bonfim Carmem8,Vora Ajay9,Díaz de Heredia Cristina10,Teague Lochie11,Stein Jerry12,O’Brien Tracey A.13,Bittencourt Henrique14,Madureira Adrienne15,Strahm Brigitte16,Peters Christina17,Niemeyer Charlotte16,Gluckman Eliane2,Rocha Vanderson2

Affiliation:

1. Department of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Bambino Gesù, Università di Pavia, Rome, Italy;

2. Eurocord, Hôpital Saint Louis Assistance Publique-Hôpitaux de Paris, University Paris VII, Paris, France;

3. Rome Transplant Network, University Tor Vergata, Rome, Italy;

4. Center for International Blood and Marrow Transplant Research, Milwaukee, WI;

5. Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN;

6. Pediatric Hematology-Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;

7. Division of Blood and Marrow Transplantation, Department of Pediatrics, Duke University Medical Center, Durham, NC;

8. Bone Marrow Transplant, Federal University of Parana, Curitiba, Brasil;

9. Department of Haematology, Sheffield Children’s Hospital, Sheffield, UK;

10. Hospital Vall d’Hebron, Barcelona, Spain;

11. Starship Hospital, Auckland, New Zealand;

12. Department of Pediatric Hematology Oncology and BMT Unit, Schneider Children’s Medical Center of Israel, Petah-Tikva, Israel;

13. Cord & Marrow Transplant Program, Centre for Children’s Cancer & Blood Disorders, Sydney Children's Hospital, Sydney, Australia;

14. Centre Hospitalier Universitaire Sainte-Justine, Montreal, Canada;

15. Instituto Nacional de Cancer, Rio de Janeiro, Brasil;

16. Division of Pediatric Hematology and Oncology, University Children's Hospital Freiburg, Freiburg, Germany; and

17. Paediatric Diseases Working Party-European Group for Blood and Marrow Transplantation, St-Anna Kinderspital, Vienna, Austria

Abstract

Key Points UCBT is a suitable option for children with JMML, being able to cure a relevant proportion of patients. Because disease recurrence remains the major cause of treatment failure after UCBT, strategies aimed at reducing relapse are desirable.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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