IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation-Reference-Cited by-同舟云学术

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation

Published:2013-08-29 Issue:9 Volume:122 Page:1658-1668
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wilkinson Nicole¹,Pantopoulos Kostas¹

Affiliation:

1. Lady Davis Institute for Medical Research, Jewish General Hospital, and Department of Medicine, McGill University, Montreal, QC, Canada

Abstract

Key Points IRP1 controls HIF2α mRNA translation in vivo and thereby acts as an upstream regulator of Epo expression. IRP1 deficiency leads to age-dependent erythropoietic abnormalities and misregulation of body iron metabolism via the HIF2α/Epo pathway.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/9/1658/1373633/1658.pdf

Reference48 articles.

1. Hypoxia-inducible factors in physiology and medicine.;Semenza;Cell,2012

2. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression.;Keith;Nat Rev Cancer,2012

3. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.;Kaelin;Mol Cell,2008

4. Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency.;Sanchez;Nat Struct Mol Biol,2007

5. Regulation of cellular iron metabolism.;Wang;Biochem J,2011

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