Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype

Author:

Migliorini Gabriele1,Fiege Bettina2,Hosking Fay J.1,Ma Yussanne1,Kumar Rajiv2,Sherborne Amy L.1,da Silva Filho Miguel Inacio2,Vijayakrishnan Jayaram1,Koehler Rolf3,Thomsen Hauke2,Irving Julie A.4,Allan James M.4,Lightfoot Tracy5,Roman Eve5,Kinsey Sally E.67,Sheridan Eamonn7,Thompson Pamela8,Hoffmann Per9,Nöthen Markus M.910,Mühleisen Thomas W.9,Eisele Lewin11,Zimmermann Martin12,Bartram Claus R.3,Schrappe Martin13,Greaves Mel14,Stanulla Martin12,Hemminki Kari215,Houlston Richard S.1

Affiliation:

1. Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, United Kingdom;

2. Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany;

3. Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany;

4. Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;

5. Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, United Kingdom;

6. Department of Paediatric and Adolescent Haematology and Oncology, Leeds General Infirmary, Leeds, United Kingdom;

7. Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom;

8. Cancer Immunogenetics Group, School of Cancer Sciences, University of Manchester, St. Mary's Hospital, Manchester, United Kingdom;

9. Institute of Human Genetics, University of Bonn, Bonn, Germany;

10. German Center for Neurodegenerative Diseases, Bonn, Germany;

11. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg–Essen, Essen, Germany;

12. Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany;

13. General Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany;

14. Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, United Kingdom; and

15. Center for Primary Health Care Research, Lund University, Malmö, Sweden

Abstract

Key Points Variation at 10p12.2 (PIP4K2A) and 10p14 (GATA3) influences ALL risk and tumor subtype. GATA3 genotype is a determinant of event-free survivorship.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference37 articles.

1. Geographic and ethnic variations in the incidence of childhood cancer.;Stiller;Br Med Bull,1996

2. Infection, immune responses and the aetiology of childhood leukaemia.;Greaves;Nat Rev Cancer,2006

3. Infectious illness in children subsequently diagnosed with acute lymphoblastic leukemia: modeling the trends from birth to diagnosis.;Crouch;Am J Epidemiol,2012

4. Familial risks for childhood acute lymphocytic leukaemia in Sweden and Finland: far exceeding the effects of known germline variants.;Kharazmi;Br J Haematol,2012

5. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.;Papaemmanuil;Nat Genet,2009

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