Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation

Author:

Yoshizato Tetsuichi1,Nannya Yasuhito1,Atsuta Yoshiko23,Shiozawa Yusuke14,Iijima-Yamashita Yuka5,Yoshida Kenichi1,Shiraishi Yuichi6,Suzuki Hiromichi1,Nagata Yasunobu1,Sato Yusuke1,Kakiuchi Nobuyuki1,Matsuo Keitaro7,Onizuka Makoto8,Kataoka Keisuke1,Chiba Kenichi6,Tanaka Hiroko9,Ueno Hiroo1,Nakagawa Masahiro M.1,Przychodzen Bartlomiej10,Haferlach Claudia11,Kern Wolfgang11,Aoki Kosuke1,Itonaga Hidehiro12,Kanda Yoshinobu13,Sekeres Mikkael A.10,Maciejewski Jaroslaw P.10,Haferlach Torsten11,Miyazaki Yasushi12,Horibe Keizo14,Sanada Masashi5,Miyano Satoru69,Makishima Hideki1,Ogawa Seishi1

Affiliation:

1. Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;

2. Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan;

3. Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan;

4. Department of Pediatrics, The University of Tokyo, Tokyo, Japan;

5. Department of Advanced Diagnosis, Clinical Research Center, Nagoya Medical Center, Nagoya, Japan;

6. Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan;

7. Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Aichi, Japan;

8. Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan;

9. Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan;

10. Department of Translational Hematology and Oncology Research and Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;

11. MLL Munich Leukemia Laboratory, Munich, Germany;

12. Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan;

13. Division of Hematology, Jichi Medical University, Tochigi, Japan; and

14. Clinical Research Center, Nagoya Medical Center, Nagoya, Japan

Abstract

Key Points TP53 and RAS-pathway mutations predict very poor survival, when seen with CK and MDS/MPNs, respectively. For patients with mutated TP53 or CK alone, long-term survival could be obtained with stem cell transplantation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference56 articles.

1. Myelodysplasia;Heaney;N Engl J Med,1999

2. Myelodysplastic syndromes/neoplasms, overview;Brunning,2008

3. The genetic basis of myelodysplasia and its clinical relevance;Cazzola;Blood,2013

4. Myelodysplastic syndromes;Tefferi;N Engl J Med,2009

5. Myelodysplastic syndromes–oping with ineffective hematopoiesis;Cazzola;N Engl J Med,2005

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