BCL2 expression in DLBCL: reappraisal of immunohistochemistry with new criteria for therapeutic biomarker evaluation-Reference-Cited by-同舟云学术

BCL2 expression in DLBCL: reappraisal of immunohistochemistry with new criteria for therapeutic biomarker evaluation

Published:2017-07-27 Issue:4 Volume:130 Page:489-500
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tsuyama Naoko¹²^ORCID,Sakata Seiji³,Baba Satoko³,Mishima Yuko⁴,Nishimura Noriko⁴,Ueda Kyoko⁴,Yokoyama Masahiro⁴,Terui Yasuhito⁴,Hatake Kiyohiko⁴,Kitagawa Masanobu²,Ishizuka Naoki⁵,Tomita Naoto⁶,Takeuchi Kengo¹³^ORCID

Affiliation:

1. Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan;

2. Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan;

3. Pathology Project for Molecular Targets,

4. Department of Hematology Oncology, and

5. Clinical Research Center, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan; and

6. Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan

Abstract

Key Points A BCL2 IHC score is a strong prognostic factor independent of the IPI and MYC protein/rearrangement status in DLBCL treated with R-CHOP. The BCL2 scoring system we propose is a simple, at-a-glance, and highly reliable system, which was confirmed by an image analysis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/4/489/1405464/blood759621.pdf

Reference46 articles.

1. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling;Alizadeh;Nature,2000

2. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma;Rosenwald;N Engl J Med,2002

3. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy;Czabotar;Nat Rev Mol Cell Biol,2014

4. Involvement of the bcl-2 gene in human follicular lymphoma;Tsujimoto;Science,1985

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