Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults-Reference-Cited by-同舟云学术

Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults

Published:2017-07-13 Issue:2 Volume:130 Page:167-175
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Milne Paul¹,Bigley Venetia¹,Bacon Chris M.²³,Néel Antoine⁴,McGovern Naomi¹,Bomken Simon²,Haniffa Muzlifah¹,Diamond Eli L.⁵,Durham Benjamin H.⁵,Visser Johannes⁶,Hunt David⁷,Gunawardena Harsha⁸,Macheta Mac⁹,McClain Kenneth L.¹⁰,Allen Carl¹⁰,Abdel-Wahab Omar⁵,Collin Matthew¹

Affiliation:

1. Institute of Cellular Medicine and

2. Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;

3. Department of Cellular Pathology, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom;

4. Internal Medicine Department, Hôtel-Dieu University Hopital, Nantes, France;

5. Memorial Sloan Kettering Cancer Center, New York, NY;

6. East Midlands Children’s and Young Persons’ Integrated Cancer Service, Leicester Children’s Hospital, Leicester, United Kingdom;

7. Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom;

8. Rheumatology Department, North Bristol National Health Service Trust, Bristol, United Kingdom;

9. Blackpool Teaching Hospitals National Health Service Foundation Trust, Blackpool, United Kingdom; and

10. Texas Children’s Cancer Center, Baylor College of Medicine, Houston, TX

Abstract

Key Points Bone marrow progenitors, monocytes, and myeloid DCs contain BRAFV600E alleles in adults with LCH and ECD. Mutant allele distribution is not disease specific, but precursors have distinct LCH-like and macrophage differentiation capacities.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/2/167/1403864/blood757823.pdf

Reference39 articles.

1. Recurrent BRAF mutations in Langerhans cell histiocytosis;Badalian-Very;Blood,2010

2. BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis;Sahm;Blood,2012

3. High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses;Haroche;Blood,2012

4. B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease;Satoh;PLoS One,2012

5. BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups;Berres;J Exp Med,2014

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