Aryl hydrocarbon receptor–dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets-Reference-Cited by-同舟云学术

Aryl hydrocarbon receptor–dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets

Published:2016-05-05 Issue:18 Volume:127 Page:2231-2240
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Strassel Catherine¹²³⁴,Brouard Nathalie¹²³⁴,Mallo Lea¹²³⁴,Receveur Nicolas¹²³⁴,Mangin Pierre¹²³⁴,Eckly Anita¹²³⁴,Bieche Ivan⁵,Tarte Karin⁶⁷⁸,Gachet Christian¹²³⁴,Lanza François¹²³⁴

Affiliation:

1. Unité Mixte de Recherche (UMR) S949 INSERM, Strasbourg, France;

2. Etablissement Français du Sang-Alsace, Strasbourg, France;

3. Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France;

4. Université de Strasbourg, Strasbourg, France;

5. Unité de Pharmacogénomique, Service de Génétique, Institut Curie, Paris, France;

6. UMR INSERM U917, Rennes, France;

7. Université Rennes 1, Rennes, France; and

8. Etablissement Français du Sang-Bretagne, Rennes, France

Abstract

Key Points Emergence of a CD34+CD41low population with a high capacity to generate proplatelet-producing MKs and functional platelet-like elements. Platelet production is inversely correlated to CYP1B1 expression, a target of the aryl hydrocarbon receptor.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/18/2231/1393117/2231.pdf

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5. Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes.;Nakagawa;Exp Hematol,2013

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