Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms

Author:

Araki Marito1,Yang Yinjie2,Masubuchi Nami23,Hironaka Yumi2,Takei Hiraku2,Morishita Soji1,Mizukami Yoshihisa24,Kan Shin25,Shirane Shuichi2,Edahiro Yoko2,Sunami Yoshitaka2,Ohsaka Akimichi1,Komatsu Norio2

Affiliation:

1. Department of Transfusion Medicine and Stem Cell Regulation,

2. Department of Hematology,

3. Research Institute for Disease of Old Age,

4. Center for Genomic and Regenerative Medicine, and

5. Leading Center for the Development and Research of Cancer Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Abstract

Key Points Mutant CALR induces TPO-independent growth in the human megakaryocytic cell line UT-7/TPO. Mutant CALR binds to the TPO receptor, inducing phosphorylation of JAK2 and activating downstream signaling.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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