Dexamethasone vs prednisone in induction treatment of pediatric ALL: results of the randomized trial AIEOP-BFM ALL 2000

Author:

Möricke Anja1,Zimmermann Martin2,Valsecchi Maria Grazia34,Stanulla Martin2,Biondi Andrea45,Mann Georg6,Locatelli Franco7,Cazzaniga Giovanni5,Niggli Felix8,Aricò Maurizio9,Bartram Claus R.10,Attarbaschi Andishe6,Silvestri Daniela34,Beier Rita211,Basso Giuseppe12,Ratei Richard13,Kulozik Andreas E.14,Lo Nigro Luca15,Kremens Bernhard11,Greiner Jeanette16,Parasole Rosanna17,Harbott Jochen18,Caruso Roberta7,von Stackelberg Arend19,Barisone Elena20,Rössig Claudia21,Conter Valentino4,Schrappe Martin1

Affiliation:

1. Department of Pediatrics, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany;

2. Division of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany;

3. Medical Statistics Unit, Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza, Italy;

4. Department of Pediatrics, University of Milano-Bicocca, Ospedale S. Gerardo, Monza, Italy;

5. Centro M. Tettamanti, Clinica Pediatrica Università Milano-Bicocca, Monza, Italy;

6. Department of Pediatrics, St. Anna Children’s Cancer Research Institute and St. Anna Children’s Hospital, Medical University School, Vienna, Austria;

7. Department of Pediatric Hemato-Oncology, Ospedale Bambin Gesù, Rome, University of Pavia, Pavia, Italy;

8. Department of Pediatric Oncology, University Children’s Hospital, Zürich, Switzerland;

9. Direzione Generale, Azienda Sanitaria Provinciale, Ragusa, Italy;

10. Institute of Human Genetics, Ruprecht-Karls-University, Heidelberg, Germany;

11. Department of Pediatric Hematology and Oncology, University Hospital, Essen, Germany;

12. Pediatric Hemato-Oncology, Department of Women's and Children's Health, University of Padova, Padova, Italy;

13. Hematology/Oncology, Robert-Rössle-Klinik at the HELIOS Klinikum, Charité, Berlin, Germany;

14. Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany;

15. Department of Pediatric Hemato-Oncology, Azienda Policlinico–Ospedale Vittorio Emanuele, Catania, Italy;

16. Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland;

17. Department of Pediatric Hematology and Oncology, Santobono-Pausilipon Hospital, Napoli, Italy;

18. Pediatric Hematology and Oncology, Justus-Liebig University, Gießen, Germany;

19. Pediatric Hematology and Oncology, Charité Medical Center, Humboldt University, Berlin, Germany;

20. Department of Pediatric Hemato-Oncology, Regina Margherita Children’s Hospital, Torino, Italy; and

21. Department of Pediatric Hematology and Oncology, University Children’s Hospital, Münster, Germany

Abstract

Key Points Dexamethasone vs prednisone in induction of pediatric ALL led to significant relapse reduction and increased treatment-related mortality. No overall survival benefit was achieved with dexamethasone except in the subset of patients with T-cell ALL and good early treatment response.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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