Anti–factor VIII IgA as a potential marker of poor prognosis in acquired hemophilia A: results from the GTH-AH 01/2010 study-Reference-Cited by-同舟云学术

Anti–factor VIII IgA as a potential marker of poor prognosis in acquired hemophilia A: results from the GTH-AH 01/2010 study

Published:2016-05-12 Issue:19 Volume:127 Page:2289-2297
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tiede Andreas¹^ORCID,Hofbauer Christoph J.²,Werwitzke Sonja¹,Knöbl Paul³,Gottstein Saskia⁴,Scharf Rüdiger E.⁵,Heinz Jürgen⁶,Groß Jürgen⁷,Holstein Katharina⁸,Dobbelstein Christiane¹,Scheiflinger Fritz²,Koch Armin⁹,Reipert Birgit M.²

Affiliation:

1. Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany;

2. Research and Innovation, Baxalta, Vienna, Austria;

3. Hematology and Hemostasis, Vienna Medical University, Vienna, Austria;

4. Internal Medicine, Vivantes Clinic Friedrichshain, Berlin, Germany;

5. Hemostasis, Hemotherapy, and Transfusion Medicine, Heinrich Heine University Medical Center, Düsseldorf, Germany;

6. Hematology and Oncology, Freiburg University Hospital, Freiburg, Germany;

7. Clinical Hemostaseology and Transfusion Medicine, Saarland University Hospital, Homburg/Saar, Germany;

8. Hematology and Oncology, University Hospital Eppendorf, Hamburg, Germany; and

9. Biometry, Hannover Medical School, Hannover, Germany

Abstract

Key Points This study is the first to assess the prognostic value of FVIII-specific antibody data in patients with AHA. Anti-FVIII IgA, but not immunoglobulin G, autoantibodies at baseline are potential predictors of recurrence and poor outcome of AHA.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/19/2289/1393138/2289.pdf

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