C-reactive protein enhances murine antibody–mediated transfusion-related acute lung injury-Reference-Cited by-同舟云学术

C-reactive protein enhances murine antibody–mediated transfusion-related acute lung injury

Published:2015-12-17 Issue:25 Volume:126 Page:2747-2751
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kapur Rick¹²,Kim Michael¹,Shanmugabhavananthan Shanjeevan¹²,Liu Jonathan¹,Li Yuan¹,Semple John W.¹²³⁴⁵

Affiliation:

1. The Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada;

2. Canadian Blood Services, Toronto, ON, Canada; and

3. Departments of Pharmacology,

4. Medicine, and

5. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

Abstract

Key Points CRP enhances antibody-mediated lung damage when infused into TRALI-resistant mice. CRP and TRALI-inducing antibodies generate a synergistic increase in MIP-2 production and pulmonary neutrophil accumulation in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/25/2747/1389992/2747.pdf

Reference37 articles.

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3. The role of donor antibodies in the pathogenesis of transfusion-related acute lung injury: a systematic review.;Middelburg;Transfusion,2008

4. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.;Looney;J Clin Invest,2006

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