N-linked glycan stabilization of the VWF A2 domain-Reference-Cited by-同舟云学术

N-linked glycan stabilization of the VWF A2 domain

Published:2016-03-31 Issue:13 Volume:127 Page:1711-1718
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lynch Christopher J.¹^ORCID,Lane David A.¹^ORCID

Affiliation:

1. Centre for Haematology, Department of Medicine, Imperial College London, London, United Kingdom

Abstract

Key Points Glycosylation at N1574 stabilizes the VWF A2 domain against unfolding and proteolysis by ADAMTS13, and its first GlcNAc is the critical element. Y1544 is a likely interacting residue with N1574-GlcNAc, and its mutation to aspartic acid stabilizes the domain in the absence of the glycan.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/13/1711/1392459/1711.pdf

Reference32 articles.

1. Sequence and structure relationships within von Willebrand factor.;Zhou;Blood,2012

2. Biochemistry and genetics of von Willebrand factor.;Sadler;Annu Rev Biochem,1998

3. Amino acid sequence of human von Willebrand factor.;Titani;Biochemistry,1986

4. Shear-dependent changes in the three-dimensional structure of human von Willebrand factor.;Siedlecki;Blood,1996

5. Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein Ib.;Emsley;J Biol Chem,1998

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