Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors

Author:

Kanate Abraham S.1,Mussetti Alberto2,Kharfan-Dabaja Mohamed A.3,Ahn Kwang W.45,DiGilio Alyssa4,Beitinjaneh Amer6,Chhabra Saurabh7,Fenske Timothy S.8,Freytes Cesar9,Gale Robert Peter10,Ganguly Siddhartha11,Hertzberg Mark12,Klyuchnikov Evgeny13,Lazarus Hillard M.14,Olsson Richard1516,Perales Miguel-Angel17,Rezvani Andrew18,Riches Marcie19,Saad Ayman20,Slavin Shimon21,Smith Sonali M.22,Sureda Anna23,Yared Jean24,Ciurea Stefan25,Armand Philippe26,Salit Rachel27,Bolaños-Meade Javier28,Hamadani Mehdi4

Affiliation:

1. Osborn Hematopoietic Malignancy and Transplantation Program, West Virginia University, Morgantown, WV;

2. S.C. Ematologia e Trapianto di Midollo Osseo, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy;

3. Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;

4. Center for International Blood and Marrow Transplant Research, Department of Medicine and

5. Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI;

6. Division of Hematology/Oncology, Department of Medicine, Emily Couric Clinical Cancer Center, Charlottesville, VA;

7. Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC;

8. Department of Hematology/Oncology, Froedtert Memorial Lutheran Hospital, Milwaukee, WI;

9. South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX;

10. Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom;

11. Blood and Marrow Transplantation, Division of Hematology and Oncology, University of Kansas Medical Center, Kansas City, KS;

12. Department of Haematology, Prince of Wales Hospital, Randwick, NSW, Australia;

13. Department for Stem Cell Transplantation, University Cancer Center, Hamburg, Germany;

14. Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH;

15. Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden;

16. Centre for Clinical Research Sormland, Uppsala University, Uppsala, Sweden;

17. Adult Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;

18. Blood and Marrow Transplantation, Stanford University Medical Center, Stanford, CA;

19. Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC;

20. Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL;

21. The International Center for Cell Therapy & Cancer Immunotherapy, Tel Aviv, Israel;

22. Section of Hematology/Oncology, The University of Chicago, Chicago, IL;

23. Servei d’Hematologia, Institut Catala d’Oncologia, Hospital Duran I Reynals, Barcelona, Spain;

24. Blood & Marrow Transplantation Program, Division of Hematology/Oncology, Department of Medicine, Greenebaum Cancer Center, University of Maryland, Baltimore, MD;

25. Department of Hematology, MD Anderson Cancer Center, Houston, TX;

26. Department of Medical Oncology/Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA;

27. Department of Hematology/Oncology, Fred Hutchinson Cancer Research Center, Seattle, WA; and

28. Division of Hematologic Malignancies, Johns Hopkins University Sidney Kimmel Cancer Center, Baltimore, MD

Abstract

Key Points Risk of grade III-IV acute and chronic GVHD is significantly lower with haploidentical compared with URD transplantation. Relapse risk, NRM, PFS, and OS was similar in haploidentical transplants compared with unrelated donor transplants.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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