Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates-Reference-Cited by-同舟云学术

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

Published:2016-05-19 Issue:20 Volume:127 Page:2416-2426
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Peterson Christopher W.¹,Wang Jianbin²,Norman Krystin K.¹,Norgaard Zachary K.¹,Humbert Olivier¹,Tse Collette K.²,Yan Jenny J.²,Trimble Richard G.²,Shivak David A.²,Rebar Edward J.²,Gregory Philip D.²,Holmes Michael C.²,Kiem Hans-Peter¹³⁴

Affiliation:

1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Sangamo BioSciences, Richmond, CA; and

3. Department of Medicine and

4. Department of Pathology, University of Washington, Seattle, WA

Abstract

Key Points This study is the first to show that genome-editing approaches can modify multilineage, long-term repopulating cells in a large animal model. We demonstrate that the persistence of genome-edited hematopoietic stem cells can be tracked in vivo in a mutation-specific manner.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/20/2416/1393545/2416.pdf

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