Ranking reactive glutamines in the fibrinogen αC region that are targeted by blood coagulant factor XIII-Reference-Cited by-同舟云学术

Ranking reactive glutamines in the fibrinogen αC region that are targeted by blood coagulant factor XIII

Published:2016-05-05 Issue:18 Volume:127 Page:2241-2248
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mouapi Kelly Njine¹,Bell Jacob D.¹,Smith Kerrie A.²,Ariëns Robert A. S.²,Philippou Helen²,Maurer Muriel C.¹

Affiliation:

1. Department of Chemistry, University of Louisville, Louisville, KY; and

2. Thrombosis and Tissue Repair Group, Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine and Multidisciplinary Cardiovascular Research Centre, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

Abstract

Key Points FXIIIa exhibits a preference for Q237 in crosslinking reactions within fibrinogen αC (233-425) followed by Q328 and Q366. None of the reactive glutamines in αC 233-425 (Q237, Q328, and Q366) are required to react first before the others can crosslink.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/18/2241/1393031/2241.pdf

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