Loss of DGKε induces endothelial cell activation and death independently of complement activation-Reference-Cited by-同舟云学术

Loss of DGKε induces endothelial cell activation and death independently of complement activation

Published:2015-02-05 Issue:6 Volume:125 Page:1038-1046
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bruneau Sarah¹,Néel Mélanie¹,Roumenina Lubka T.²³⁴,Frimat Marie²⁵,Laurent Lætitia¹,Frémeaux-Bacchi Véronique²⁶,Fakhouri Fadi¹

Affiliation:

1. INSERM Unité Mixte de Recherche S-1064, Institut de Transplantation Urologie-Nephrologie, Centre Hospitalier Universitaire de Nantes, University of Nantes, Nantes, France;

2. INSERM Unité Mixte de Recherche S-1138, Cordeliers Research Center, Complement and Diseases Team, Paris, France;

3. Université Paris Descartes Sorbonne Paris-Cité, Paris, France;

4. Université Pierre et Marie Curie (Paris-6), Paris, France;

5. Service de Néphrologie, Hôpital Claude Huriez, Centre Hospitalier Universitaire de Lille, France; and

6. Assistance Publique—Hôpitaux de Paris, Service d’Immunologie Biologique, Hôpital Européen Georges Pompidou, Paris, France

Abstract

Key Points Loss of DGKε in endothelial cells induces cell death, impairs angiogenic responses, and leads to an activated and prothrombotic phenotype. DGKE silencing in resting endothelial cells does not affect complement activation at their surface.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/6/1038/1387003/1038.pdf

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