Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation

Author:

Li Yueying1,Jin Chen12,Bai Hao34,Gao Yongxing34,Sun Shu12,Chen Lei12,Qin Lei12,Liu Paul P.5,Cheng Linzhao34,Wang Qian-Fei12

Affiliation:

1. Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China;

2. University of Chinese Academy of Sciences, Beijing, China;

3. Division of Hematology, Department of Medicine and

4. Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD; and

5. Translational and Functional Genomics Branch, National Institutes of Health, National Human Genome Research Institute, Bethesda, MD

Abstract

Key Points NOTCH4 is a RUNX1 direct target the expression of which is negatively regulated by RUNX1 during human megakaryopoiesis. Inhibition of NOTCH4 by genetic approach or chemical inhibitors enhances MK production from human iPSCs and cord-blood CD34+ cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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